CLDN18

Developmental stage

Expressed in the lungs from 23 weeks onwards, expression increases during the third trimester resulting in significantly higher expression at birth.

Function

The protein expressed by the gene CLDN18 plays a major role in the tight junction-specific obliteration of the intercellular space through calcium-independent cell-adhesion activity. This supplementary information is collated from multiple sources and compiled automatically.

Sequence Similarities

Belongs to the claudin family.

Tissue Specificity

Isoform A1

Expression is restricted to the lung.

Isoform A2

Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level).

Cellular localization

• Cell junction
• Tight junction
• Cell membrane
• Multi-pass membrane protein
• Localizes to tight junctions in epithelial cells.
• Isoform A1
• Cell junction
• Tight junction
• Isoform A2
• Cell junction
• Tight junction
• Lateral cell membrane

Alternative names

UNQ778/PRO1572, CLDN18, Claudin-18

Database links

swissprot:P56856 entrezGene:51208 swissprot:P56856-2 omim:609210