CLDN8
Function
Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity). May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:36008380). Cannot form tight junction strands on its own (PubMed:36008380).
Post-translational modifications
Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation.
Sequence Similarities
Belongs to the claudin family.
Tissue Specificity
Expressed in the epididymis, mainly in the caput segment.
Cellular localization
- Cell junction
- Tight junction
- Cell membrane
- Multi-pass membrane protein
- Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells.
Alternative names
UNQ779/PRO1573, CLDN8, Claudin-8