Cleavage stimulation factor subunit 2
Function
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs.
Involvement in disease
Intellectual developmental disorder, X-linked 113
XLID113
A disorder characterized by mild intellectual disability, and developmental delay mainly affecting verbal and non-verbal communication skills. Motor development is normal.
None
The disease is caused by variants affecting the gene represented in this entry.
Cellular localization
- Nucleus
- Localized with DDX1 in cleavage bodies.
Alternative names
Cleavage stimulation factor subunit 2, CF-1 64 kDa subunit, Cleavage stimulation factor 64 kDa subunit, CSTF 64 kDa subunit, CstF-64, CSTF2