Clec10a
Developmental stage
Detected in 7 dpc, 11 dpc, 15 dpc and 17 dpc embryo.
Function
Recognizes terminal galactose and N-acetylgalactosamine units. May participate in the interaction between tumoricidal macrophages and tumor cells. Plays a role in the recruitment of inflammatory monocytes to adipose tissue in diet-induced obesity.
Tissue Specificity
Detected in lymph node in the subcapsular sinus, interfollicular regions, T and B-cell boundary and in the areas surrounding high endothelial venules (at protein level). Expressed on the surface of activated macrophages. Expressed in heart, lung, testis, skeletal muscle, spleen, brain, kidney and thymus. Expressed in P388, RAW 264.7 and M1 cell lines.
Cellular localization
- Membrane
- Single-pass type II membrane protein
Alternative names
Mgl, Mgl1, Clec10a, C-type lectin domain family 10 member A, MMGL, Macrophage asialoglycoprotein-binding protein 1, Macrophage galactose/N-acetylgalactosamine-specific lectin, M-ASGP-BP-1