Clec1b
Function
C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2.
Post-translational modifications
Glycosylated.
Phosphorylated on tyrosine residue in response to rhodocytin binding.
Tissue Specificity
Hematopoietic cells, megakaryocytes and platelets.
Cellular localization
- Membrane
- Single-pass type II membrane protein
Alternative names
Clec2, Clec1b, C-type lectin domain family 1 member B, C-type lectin-like receptor 2, CLEC-2