CLEC2A
Function
Membrane-bound protein expressed mainly on keratinocytes which acts as a ligand to stimulate the activating receptor NKp65/KLRF2, expressed on the surface of natural killer (NK) cells (PubMed:25510854). Facilitates therbey dedicated immune recognition of keratinocytes leading to natural killer cell mediated cytotoxicity (PubMed:20194751). Plays also a role in modulating the extent of T-cell expansion (PubMed:18550855).
Post-translational modifications
N-glycosylated.
Tissue Specificity
Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
Alternative names
KACL, UNQ5792/PRO19597, CLEC2A, C-type lectin domain family 2 member A, Keratinocyte-associated C-type lectin, Proliferation-induced lymphocyte-associated receptor, PILAR