CLEC2B
Function
Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells.
Post-translational modifications
(Microbial infection) Ubiquitinated by human herpesvirus 8 protein K5, leading to endolysosomal degradation.
N-linked glycosylated; required to enable surface expression and the extent of surface expression correlates with the number of functional conventional N-glycosylation sites.
Tissue Specificity
Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
- Golgi apparatus membrane
- Resting NK cells contain intracellular stores of CLEC2B associated with the Golgi complex.
Alternative names
AICL, CLECSF2, IFNRG1, CLEC2B, C-type lectin domain family 2 member B, Activation-induced C-type lectin, C-type lectin superfamily member 2, IFN-alpha-2b-inducing-related protein 1