CLEC2D

Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:16339513, PubMed:20843815). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates the release of interferon-gamma (PubMed:15104121). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).

N-glycosylated.

Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells.

• Cell membrane
• Single-pass type II membrane protein
• Isoform 2
• Endoplasmic reticulum
• Isoform 4
• Endoplasmic reticulum

CLAX, LLT1, OCIL, CLEC2D, C-type lectin domain family 2 member D, Lectin-like NK cell receptor, Lectin-like transcript 1, Osteoclast inhibitory lectin, LLT-1

• entrezGene:29121
• omim:605659
• swissprot:Q9UHP7

Proteins

Immunology & Infectious Disease

21849Da