CLEC4G

Function

Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.

(Microbial infection) Acts as a receptor for Japanese encephalitis virus.

(Microbial infection) Acts as a receptor for Ebolavirus.

(Microbial infection) Acts as a receptor for SARS-CoV.

(Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088).

Tissue specificity

Expressed exclusively in fetal and adult liver and in lymph nodes. Specifically expressed by endothelial cells lining lymph node and liver sinuses (at protein level).

Cellular localization

• Cell membrane
• Single-pass type II membrane protein

Alternative names

• C-type lectin domain family 4 member G
• Liver and lymph node sinusoidal endothelial cell C-type lectin
• LSECtin
• CLEC4G
• UNQ431/PRO792

Database links

• entrezGene:339390
• omim:616256
• swissprot:Q6UXB4

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

32562Da