CLEC4G
Function
Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.
(Microbial infection) Acts as a receptor for Japanese encephalitis virus.
(Microbial infection) Acts as a receptor for Ebolavirus.
(Microbial infection) Acts as a receptor for SARS-CoV.
(Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088).
Tissue Specificity
Expressed exclusively in fetal and adult liver and in lymph nodes. Specifically expressed by endothelial cells lining lymph node and liver sinuses (at protein level).
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
Alternative names
UNQ431/PRO792, CLEC4G, C-type lectin domain family 4 member G, Liver and lymph node sinusoidal endothelial cell C-type lectin, LSECtin