CLEC9A

Function

Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.

Post-translational modifications

N-glycosylated.

Tissue Specificity

In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.

Cellular localization

• Membrane
• Single-pass type II membrane protein

Alternative names

CD370, UNQ9341/PRO34046, CLEC9A, C-type lectin domain family 9 member A

Database links

swissprot:Q6UXN8 entrezGene:283420 omim:612252

Other research areas

• Immunology & Infectious Disease