Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
Isoform 1
Not glycosylated.
Isoform 4
N-glycosylated.
Isoform 4 expressed at high levels by CD8(+) dendritic cells (DCs), and at low levels by plasmacytoid DCs but not by other hematopoietic cells.
CD370, Dngr-1, Clec9a, C-type lectin domain family 9 member A, Dendritic cell natural killer lectin group receptor 1
Proteins
Immuno-oncology
27014Da
We found 6 products in 1 category
ab104909
ab104903