Clec9a

Function

Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.

Post-translational modifications

Isoform 1

Not glycosylated.

Isoform 4

N-glycosylated.

Tissue Specificity

Isoform 4 expressed at high levels by CD8(+) dendritic cells (DCs), and at low levels by plasmacytoid DCs but not by other hematopoietic cells.

Cellular localization

• Membrane
• Single-pass type II membrane protein

Alternative names

CD370, Dngr-1, Clec9a, C-type lectin domain family 9 member A, Dendritic cell natural killer lectin group receptor 1

Database links

swissprot:Q8BRU4 entrezGene:232414

Other research areas

• Immunology & Infectious Disease