CLGN
Function
Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).
Sequence Similarities
Belongs to the calreticulin family.
Tissue Specificity
Detected in testis (at protein level). Detected in testis.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass type I membrane protein
Alternative names
Calmegin, CLGN