CLK3
Function
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Post-translational modifications
Autophosphorylates on all three types of residues.
Sequence Similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
Tissue Specificity
Endothelial cells.
Cellular localization
- Isoform 1
- Nucleus
- Cytoplasm
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome
- Isoform 2
- Nucleus speckle
- Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.
Alternative names
Dual specificity protein kinase CLK3, CDC-like kinase 3, CLK3