CLMP
Developmental stage
At 7 and 8 weeks of development, it is highly abundant in the rapidly dividing cells of the central and peripheral nervous systems, the mesenchyme of the frontonasal and mandibular processes and the dermamyotome, and it is expressed in the endodermal derivatives of the foregut, midgut, and hindgut, as well as in the liver, lung, esophagus, and trachea. During midterm fetal stages, 18 and 23 weeks of development, increased expression is observed in the intestinal crypts. Midterm liver and kidney tissues strongly express CLMP in the parenchyma of the lobules and cortex, respectively.
Function
May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.
Involvement in disease
Congenital short bowel syndrome
CSBS
A disease characterized by a shortened small intestine, intestinal malrotation, and malabsorption. The mean length of the small intestine in CSBS patients is approximately 50 cm, compared with a normal length at birth of 190-280 cm. Patients with CSBS may develop severe malnutrition as a result of the hugely reduced absorptive surface of the small intestine. Infants require parenteral nutrition for survival. However, parenteral nutrition itself causes life-threatening complications such as sepsis and liver failure which are associated with a high rate of mortality early in life.
None
The disease is caused by variants affecting the gene represented in this entry.
Tissue Specificity
Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney and lung and at low levels in the liver and peripheral blood leukocytes. Highly abundant in the intestine during embryo and fetal development (at protein level).
Cellular localization
- Cell junction
- Tight junction
- Cell membrane
- Single-pass type I membrane protein
Alternative names
ACAM, ASAM, UNQ318/PRO363, CLMP, CXADR-like membrane protein, Adipocyte adhesion molecule, Coxsackie- and adenovirus receptor-like membrane protein, CAR-like membrane protein