Cmklr1
Function
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity).
Sequence Similarities
Belongs to the chemokine-like receptor (CMKLR) family.
Tissue Specificity
High expression in heart and lung, low in small intestines, colon, kidney, liver, uterus and brain.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Dez, Cmklr1, Chemerin-like receptor 1, Chemokine-like receptor 1, G-protein coupled chemoattractant-like receptor, G-protein coupled receptor DEZ