CMKLR2
Function
Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822). Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).
(Microbial infection) Coreceptor for HIV-1.
Sequence Similarities
Belongs to the chemokine-like receptor (CMKLR) family.
Tissue Specificity
Expressed in hippocampus.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Internalizes in presence of its ligand, TAFA1 (By similarity). Internalizes efficiently in response to RARRES2 (PubMed:27716822).
Alternative names
GPR1, CMKLR2, Chemerin-like receptor 2, Chemerin chemokine-like receptor 2, Chemokine-like receptor 2, G-protein coupled receptor 1