Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.
Belongs to the chemokine-like factor family.
Highly expressed in testis and prostate.
CKLFSF4, CMTM4, CKLF-like MARVEL transmembrane domain-containing protein 4, Chemokine-like factor superfamily member 4
Proteins
Immuno-oncology
25828Da
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