CMTM4
Function
Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.
Sequence Similarities
Belongs to the chemokine-like factor family.
Tissue Specificity
Highly expressed in testis and prostate.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
CKLFSF4, CMTM4, CKLF-like MARVEL transmembrane domain-containing protein 4, Chemokine-like factor superfamily member 4