CMTM6
Function
Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.
Sequence Similarities
Belongs to the chemokine-like factor family.
Tissue Specificity
Expressed in the leukocytes, placenta and testis.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Early endosome membrane
- Multi-pass membrane protein
- Recycling endosome membrane
- Multi-pass membrane protein
- Co-localizes with PD-L1/CD274 in the plasma membrane and in recycling endosomes.
Alternative names
CKLFSF6, CMTM6, CKLF-like MARVEL transmembrane domain-containing protein 6, Chemokine-like factor superfamily member 6