CMTM6

Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.

Belongs to the chemokine-like factor family.

Expressed in the leukocytes, placenta and testis.

• Cell membrane
• Multi-pass membrane protein
• Early endosome membrane
• Multi-pass membrane protein
• Recycling endosome membrane
• Multi-pass membrane protein
• Co-localizes with PD-L1/CD274 in the plasma membrane and in recycling endosomes.

CKLFSF6, CMTM6, CKLF-like MARVEL transmembrane domain-containing protein 6, Chemokine-like factor superfamily member 6

• entrezGene:54918
• omim:607889
• swissprot:Q9NX76

Proteins

Immuno-oncology

20419Da