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CMTM6

Function

Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.

Sequence similarities

Belongs to the chemokine-like factor family.

Tissue specificity

Expressed in the leukocytes, placenta and testis.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein
  • Early endosome membrane
  • Multi-pass membrane protein
  • Recycling endosome membrane
  • Multi-pass membrane protein
  • Co-localizes with PD-L1/CD274 in the plasma membrane and in recycling endosomes.

Alternative names

  • CKLF-like MARVEL transmembrane domain-containing protein 6
  • Chemokine-like factor superfamily member 6
  • CMTM6
  • CKLFSF6

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

20419Da