CNKSR3
Domain
The PDZ domain is required for interaction with ENaC and SGK1, but not for interaction with NEDDL4 and RAF1.
Function
Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).
Sequence Similarities
Belongs to the CNKSR family.
Cellular localization
- Cytoplasm
- Apical cell membrane
- Peripheral membrane protein
Alternative names
MAGI1, CNKSR3, Connector enhancer of kinase suppressor of ras 3, Connector enhancer of KSR 3, CNK homolog protein 3, CNKSR family member 3, Maguin-like protein, CNK3