CNOT8
Function
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Sequence Similarities
Belongs to the CAF1 family.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
CALIF, POP2, CNOT8, CCR4-NOT transcription complex subunit 8, CAF1-like protein, CAF2, CCR4-associated factor 8, Caf1b, CALIFp