CNOT9
Function
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
Sequence Similarities
Belongs to the CNOT9 family.
Tissue Specificity
Detected in spleen, thymus, prostate, testis, ovary and intestine.
Cellular localization
- Nucleus
- Cytoplasm
- P-body
- NANOS2 promotes its localization to P-body.
Alternative names
RCD1, RQCD1, CNOT9, CCR4-NOT transcription complex subunit 9, Cell differentiation protein RQCD1 homolog, Rcd-1