Cnpy3
Function
Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses.
Sequence Similarities
Belongs to the canopy family.
Cellular localization
- Endoplasmic reticulum
Alternative names
Prat4a, Tnrc5, Cnpy3, Protein canopy homolog 3, Protein associated with Tlr4, Trinucleotide repeat-containing gene 5 protein