CNTF
GeneName
CNTF
Summary
CNTF, also known as ciliary neurotrophic factor or CNF, is a 23 kDa neurotrophic cytokine that plays a vital role in the survival and differentiation of neurons. It is primarily expressed in the nervous system, particularly in glial cells and neurons, and is involved in various cellular processes such as astrocyte activation and neuron development. CNTF binds to its receptor, initiating signalling pathways that promote axon regeneration and inhibit neuronal apoptosis. It is localised in the cytoplasm, axons, and extracellular space, facilitating its role in cell signalling and neuroprotection.
Importance
CNTF is relevant to: - Neurodegenerative diseases, as it supports neuronal survival and regeneration - Retinal diseases, due to its involvement in retinal cell differentiation and protection against cell death - Muscle disorders, given its role in muscle organ morphogenesis and potential therapeutic applications in muscle regeneration - Research into cytokine signalling pathways, particularly the JAK-STAT pathway, which is crucial for understanding various biological processes and diseases.
Top Products
For researchers investigating CNTF, we recommend the well-cited polyclonal antibody, Anti-CNTF antibody (ab46172). This antibody has garnered 13 citations, highlighting its reliability and trust within the research community. It is particularly effective for immunocytochemistry (ICC), making it an excellent choice for those looking to study CNTF in cellular contexts. Its established performance in this application ensures that you can confidently explore the role of CNTF in your research. The Recombinant human CNTF protein (Active) ELISA Kit (ab283456) is an excellent option for researchers looking to measure CNTF levels in their samples.
Abcam Product Citation Summary
The data indicates that CNTF is being studied in the context of mouse brain tissues, particularly focusing on the effects of DNLA and dietary influences. The use of Western blotting suggests a detailed analysis of protein expression related to CNTF in these biological contexts.
Abcam Product Citation Table
Function
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Sequence Similarities
Belongs to the CNTF family.
Tissue Specificity
Nervous system.
Cellular localization
- Cytoplasm
Alternative names
Ciliary neurotrophic factor, CNTF