Cntn1
Function
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
Sequence Similarities
Belongs to the immunoglobulin superfamily. Contactin family.
Tissue Specificity
Expressed in the ovary and in Sertoli cells of the testis.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
Alternative names
Contactin-1, Neural cell surface protein F3, Cntn1