Cntnap1
Function
Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons (PubMed:25378149). Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells (PubMed:11395000, PubMed:25378149).
Sequence Similarities
Belongs to the neurexin family.
Tissue Specificity
Expressed in brain. In myelinated nerve fibers predominantly found in paranodal axoglial junctions. In the internodal region of myelinated axons in the CNS and the PNS also found as a thin line apposing the inner mesaxon of the myelin sheath. In PNS neurons this line forms a circumferential ring that apposes the innermost aspect of Schmidt-Lanterman incisures.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Cell junction
- Paranodal septate junction
Alternative names
Nrxn4, Contactin-associated protein 1, Caspr, Caspr1, MHDNIV, NCP1, Neurexin IV, Neurexin-4, Paranodin