Cntnap2
Developmental stage
Detected at postnatal day 8 in sciatic nerve at the paranodes and the juxtaparanodal region. Is progressively translocated to the adjacent juxtaparanodal region until it becomes completely absent from the paranodes in the adult.
Function
Required for gap junction formation (By similarity). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons (PubMed:25378149). Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction (Probable) (PubMed:25378149).
Sequence Similarities
Belongs to the neurexin family.
Tissue Specificity
In sciatic nerve predominantly found at the juxtaparanodal regions (at protein level).
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Cell projection
- Axon
- Cell junction
- Paranodal septate junction
- Expressed in the juxtaparadonal region.
Alternative names
Kiaa0868, Cntnap2, Contactin-associated protein-like 2, Cell recognition molecule Caspr2