CNTROB
Developmental stage
Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases.
Function
Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.
Tissue Specificity
Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Centriole
- Centriole-associated, asymmetrically localizes to the daughter centriole.
Alternative names
LIP8, PP1221, CNTROB, Centrobin, Centrosomal BRCA2-interacting protein, LYST-interacting protein 8