COIL
Domain
The atypical Tudor domain at the C-terminus contains two large unstructured loops, and does not bind methylated residues.
Function
Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.
Post-translational modifications
Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs.
Phosphorylated by VRK1 (PubMed:31527692). Phosphorylation during mitosis is associated with disassembly of CBs.
Sequence Similarities
Belongs to the coilin family.
Tissue Specificity
Found in all the cell types examined.
Cellular localization
- Nucleus
- Nucleus
- Cajal body
Alternative names
CLN80, COIL, Coilin, p80-coilin