COL19A1
Domain
The numerous interruptions in the triple helix may make this molecule either elastic or flexible.
Function
May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.
Post-translational modifications
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Sequence Similarities
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
Tissue Specificity
Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
Collagen alpha-1(XIX) chain, Collagen alpha-1(Y) chain, COL19A1