Col1a2
Domain
The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
Function
Type I collagen is a member of group I collagen (fibrillar forming collagen).
Post-translational modifications
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Sequence Similarities
Belongs to the fibrillar collagen family.
Tissue Specificity
Expressed in kidney glomeruli.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
Cola2, Collagen alpha-2(I) chain, Alpha-2 type I collagen