Col25a1
Function
Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (By similarity).
Post-translational modifications
Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component.
Glycosylated.
Hydroxylated on proline and lysine residues.
Tissue Specificity
Expressed predominantly in neurons with low levels also detected in heart, testis and eye.
Cellular localization
- Membrane
- Single-pass type II membrane protein
- After proteolytic cleavage, CLAC is secreted.
Alternative names
Collagen alpha-1(XXV) chain, CLAC-P, Col25a1