Col25a1

Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (By similarity).

Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component.

Glycosylated.

Hydroxylated on proline and lysine residues.

Expressed predominantly in neurons with low levels also detected in heart, testis and eye.

• Membrane
• Single-pass type II membrane protein
• After proteolytic cleavage, CLAC is secreted.

Collagen alpha-1(XXV) chain, CLAC-P, Col25a1

• swissprot:Q99MQ5

Proteins

Neuroscience

65377Da