COL3A1
GeneName
COL3A1
Summary
COL3A1, also known as collagen III, is a 139kDa protein that forms a crucial component of the extracellular matrix (ECM). It is primarily expressed in connective tissues and is secreted into the extracellular space, where it contributes to the structural integrity and tensile strength of tissues. COL3A1 is involved in various biological processes, including collagen fibril organisation, cell-matrix adhesion, and the morphogenesis of smooth muscle tissue and the aorta. Additionally, it plays roles in wound healing, fibroblast proliferation, and the development of various organs, such as the heart and lungs. The protein interacts with integrins and other growth factors, influencing cellular responses and tissue homeostasis.
Importance
COL3A1 is relevant to: - Understanding connective tissue disorders, such as Ehlers-Danlos syndrome, due to its role in collagen structure and function - Investigating cardiovascular diseases, given its involvement in aorta development and vascular integrity - Exploring mechanisms of wound healing and tissue regeneration, as it is crucial for ECM organisation - Studying developmental biology, particularly in relation to organogenesis and embryonic development - Researching its role in cancer biology, as alterations in collagen composition can affect tumour microenvironments and metastasis
Top Products
For researchers investigating COL3A1, we recommend two excellent primary antibodies that cater to a variety of applications. The first is the highly regarded polyclonal antibody, Anti-Collagen I + Collagen III antibody (ab34710), which has garnered an impressive 2238 citations, underscoring its reliability in Western blotting (WB) and immunohistochemistry (IHC). This antibody is a trusted choice for those studying collagen types I and III.In addition, we offer the recombinant monoclonal antibody, Anti-Collagen III antibody [EPR17673] (ab184993). This product has been validated for use in multiple applications, including WB, immunocytochemistry (ICC), flow cytometry (FC), and immunoprecipitation (IP). With 147 citations, it is gaining traction in the research community and provides the batch-to-batch consistency that is often essential for experimental reproducibility. Together, these antibodies provide robust options for COL3A1 research. The Native Human Collagen III protein ELISA Kit (ab7535), supported by 6 citations, is an excellent option for researchers looking to accurately measure COL3A1 levels in their samples.
Abcam Product Citation Summary
The data indicates a significant focus on the role of COL3A1 in various fibrotic conditions and tissue responses across multiple species, particularly in Rattus norvegicus and Mus musculus. Studies often involve Western blotting and immunohistochemistry applications, highlighting the importance of COL3A1 in renal, cardiac, and pulmonary fibrosis, as well as its expression in response to various stimuli such as Ghrelin and TGF-β1. The research underscores COL3A1's relevance in understanding collagen dynamics in health and disease.
Abcam Product Citation Table
Domain
The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
Function
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
Involvement in disease
Ehlers-Danlos syndrome, vascular type
EDSVASC
A severe form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSVASC is an autosomal dominant disease characterized by joint and dermal manifestations as in other forms of the syndrome, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas.
None
The disease is caused by variants affecting the gene represented in this entry.
Polymicrogyria with or without vascular-type Ehlers-Danlos syndrome
PMGEDSV
An autosomal recessive disorder with a highly variable phenotype and onset in early childhood. Disease features include cobblestone-like malformation of the cortex, polymicrogyria, intellectual and motor developmental delay, small joint hypermobility, vascular fragility, aneurysms, thin translucent skin and easy bruising, congenital heart defects, and foot deformities. Early death due to vascular dissection may occur.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
Sequence Similarities
Belongs to the fibrillar collagen family.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
Collagen alpha-1(III) chain, COL3A1