COMMD3
Function
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).
Tissue Specificity
Widely expressed with highest expression in thymus.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
BUP, C10orf8, COMMD3, COMM domain-containing protein 3, Protein Bup, Protein PIL