COPS7A
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Post-translational modifications
Phosphorylated by CK2 and PKD kinases.
Sequence Similarities
Belongs to the CSN7/EIF3M family. CSN7 subfamily.
Tissue Specificity
Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
CSN7A, DERP10, COPS7A, COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a