CORO1A
Function
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
Involvement in disease
Immunodeficiency 8 with lymphoproliferation
IMD8
A disease of the immune system leading to recurrent infections, and characterized by CD4+ T-cells lymphopenia. Patients can develop B-cell lymphoproliferation associated with Epstein-Barr virus infection.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.
Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.
Sequence Similarities
Belongs to the WD repeat coronin family.
Tissue Specificity
Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cytoplasm
- Cell cortex
- Cytoplasmic vesicle
- Phagosome membrane
- In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity).
Alternative names
CORO1, CORO1A, Coronin-1A, Coronin-like protein A, Coronin-like protein p57, Tryptophan aspartate-containing coat protein, Clipin-A, TACO