CORO7
Function
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
Post-translational modifications
The membrane-associated form is phosphorylated on tyrosine residues.
Ubiquitinated via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: 'Lys-33'-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID.
Sequence Similarities
Belongs to the WD repeat coronin family.
Tissue Specificity
Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.
Cellular localization
- Golgi apparatus membrane
- Golgi apparatus
- trans-Golgi network
- Cytoplasmic vesicle
- Cytoplasm
- Cytosol
- Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.
Alternative names
Coronin-7, Crn7, 70 kDa WD repeat tumor rejection antigen homolog, CORO7