COTL1
Function
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
Sequence Similarities
Belongs to the actin-binding proteins ADF family. Coactosin subfamily.
Tissue Specificity
Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Nucleus
Alternative names
CLP, COTL1, Coactosin-like protein