COX17

Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).

Acetylation by KAT8 promotes assembly of the mitochondrial respiratory chain complex IV (CIV).

Belongs to the COX17 family.

Ubiquitous.

• Mitochondrion intermembrane space
• Cytoplasm

Cytochrome c oxidase copper chaperone, COX17

• entrezGene:10063
• omim:604813
• swissprot:Q14061

Proteins

6915Da