COX17
Function
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Post-translational modifications
Acetylation by KAT8 promotes assembly of the mitochondrial respiratory chain complex IV (CIV).
Sequence Similarities
Belongs to the COX17 family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Mitochondrion intermembrane space
- Cytoplasm
Alternative names
Cytochrome c oxidase copper chaperone, COX17