CP
GeneName
CP
Summary
Ceruloplasmin (CP) is a 122 kDa copper-carrying protein that is synthesised primarily in the liver and secreted into the bloodstream. It plays a crucial role in copper metabolism and iron homeostasis, functioning as a ferroxidase that facilitates the oxidation of ferrous iron to ferric iron, thereby promoting iron transport. CP is also involved in the regulation of reactive oxygen species through its glutathione peroxidase activity. The protein is found in various cellular compartments including the extracellular region, plasma membrane, and lysosomal membrane, and is associated with blood microparticles and extracellular exosomes.
Importance
Ceruloplasmin is relevant to: - Disorders of copper metabolism, such as Wilson’s disease, where its dysfunction leads to copper accumulation - Iron overload conditions, as it aids in iron transport and homeostasis - Oxidative stress-related diseases due to its role in modulating reactive oxygen species - Potential therapeutic targets in conditions like neurodegeneration, where copper and iron dysregulation plays a role
Top Products
For researchers investigating ceruloplasmin (CP), we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-Ceruloplasmin antibody (ab48614), which has garnered 18 citations, highlighting its reliability in research. This antibody is particularly effective for Western blotting (WB) and immunohistochemistry (IHC), making it a versatile choice for various applications. Additionally, we offer the recombinant antibody, Anti-Ceruloplasmin antibody [EPSISR6-12] (ab131220). This monoclonal antibody is validated for use in Western blotting (WB) and provides the batch-to-batch consistency that researchers often seek in their experiments. With its proven performance, this recombinant option is an excellent complement to the polyclonal antibody for those studying CP. The Anti-Ceruloplasmin antibody [EPSISR6-12] ELISA Kit (ab131220), supported by 3 citations, is an excellent option for researchers looking to accurately measure ceruloplasmin levels in their samples.
Abcam Product Citation Summary
The data indicates that CP (Ceruloplasmin) is being studied in relation to copper status and antioxidant enzymes in mouse models, as well as its expression in human ovarian cancer tissues. This suggests a potential link between CP and both nutritional status and cancer biology.
Abcam Product Citation Table
Function
Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (PubMed:16150804). Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (PubMed:14623105, PubMed:4643313, PubMed:5912351). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols (PubMed:10481051). Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis (PubMed:16906150).
Involvement in disease
Aceruloplasminemia
ACEP
An autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the multicopper oxidase family.
Tissue Specificity
Expressed by the liver and secreted in plasma.
Cellular localization
- Secreted
- Colocalizes with GCP1 in secretory intracellular compartments.
Alternative names
Ceruloplasmin, Cuproxidase ceruloplasmin, Ferroxidase ceruloplasmin, Glutathione peroxidase ceruloplasmin, Glutathione-dependent peroxiredoxin ceruloplasmin, CP