CPB2
Function
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
Post-translational modifications
N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4.
Sequence Similarities
Belongs to the peptidase M14 family.
Tissue Specificity
Plasma; synthesized in the liver.
Cellular localization
- Secreted
Alternative names
Carboxypeptidase B2, Carboxypeptidase U, Plasma carboxypeptidase B, Thrombin-activable fibrinolysis inhibitor, CPU, pCPB, TAFI, CPB2