CPLANE2
Function
Required for efficient primary cilia initiation, regulating a late step in cilia initiation. Plays a role in the final maturation of the mother centriole and ciliary vesicle that allows extension of the ciliary axoneme.
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cilium basal body
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Centriole
- Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:29038301). Recruitment to the centriole depends on TTBK2, INTU, and its own GTPase activity (By similarity).
Alternative names
C1orf89, RSG1, CPLANE2, Ciliogenesis and planar polarity effector 2, REM2- and Rab-like small GTPase 1