CPLX2

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).

Belongs to the complexin/synaphin family.

Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.

• Cytoplasm
• Cytosol
• Presynapse
• Nucleus
• Perikaryon
• Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation.

Complexin-2, Complexin II, Synaphin-1, CPX II, CPLX2

• entrezGene:10814
• omim:605033
• swissprot:Q6PUV4

Proteins

Neuroscience

15394Da