CPN1

Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.

Carboxypeptidase N deficiency

CPND

Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or asthma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.

None

The disease is caused by variants affecting the gene represented in this entry.

Belongs to the peptidase M14 family.

Synthesized in the liver and secreted in plasma.

• Secreted
• Extracellular space

ACBP, CPN1, Carboxypeptidase N catalytic chain, CPN, Anaphylatoxin inactivator, Arginine carboxypeptidase, Carboxypeptidase N polypeptide 1, Carboxypeptidase N small subunit, Kininase-1, Lysine carboxypeptidase, Plasma carboxypeptidase B, Serum carboxypeptidase N, SCPN

• entrezGene:1369
• omim:603103
• swissprot:P15169

Proteins

52286Da