CPNE3
Function
Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).
Post-translational modifications
Phosphorylated on serine and threonine residues (PubMed:11041869).
Sequence Similarities
Belongs to the copine family.
Tissue Specificity
Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870).
Cellular localization
- Nucleus
- Cytoplasm
- Cell membrane
- Cell junction
- Cell junction
- Focal adhesion
- Associates to the membrane in a calcium-dependent manner (PubMed:20010870). Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870, PubMed:21087455). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870).
Alternative names
CPN3, KIAA0636, CPNE3, Copine-3, Copine III