CPNE7
Domain
The C2 domain 1 is not necessary for calcium-mediated translocation and association to the plasma membrane. The C2 domain 2 is necessary for calcium-mediated translocation and association to the plasma membrane.
Function
Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
Sequence Similarities
Belongs to the copine family.
Tissue Specificity
Expressed in the brain, testis, thymus and small intestine (PubMed:10534407, PubMed:12949241).
Cellular localization
- Cytoplasm
- Nucleus
- Cell membrane
- Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455).
Alternative names
Copine-7, Copine VII, CPNE7