CPQ
Function
Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
Post-translational modifications
N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains (By similarity).
Sequence Similarities
Belongs to the peptidase M28 family.
Tissue Specificity
Mainly detected in blood plasma. Abundant in placenta and kidney. Present at low level in muscles, liver and skin fibroblasts. Not detected in brain or white blood cells (at protein level).
Cellular localization
- Endoplasmic reticulum
- Golgi apparatus
- Lysosome
- Secreted
- Secretion is stimulated by TSH/thyroid-stimulating hormone, INS/insulin and SST/somatostatin.
Alternative names
LCH1, PGCP, CPQ, Carboxypeptidase Q, Lysosomal dipeptidase, Plasma glutamate carboxypeptidase