CPSF4
Function
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
Sequence Similarities
Belongs to the CPSF4/YTH1 family.
Cellular localization
- Nucleus
Alternative names
CPSF30, NAR, NEB1, CPSF4, Cleavage and polyadenylation specificity factor subunit 4, Cleavage and polyadenylation specificity factor 30 kDa subunit, NS1 effector domain-binding protein 1, No arches homolog, CPSF 30 kDa subunit, Neb-1