CRABP2
Domain
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Function
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
Post-translational modifications
Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
Sequence Similarities
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Cellular localization
- Cytoplasm
- Endoplasmic reticulum
- Nucleus
- Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
Alternative names
Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II, CRABP-II, CRABP2