RAIDD

Domain

The Death domain mediates the interaction with PIDD1 and the formation of a complex composed of 5 PIDD1 and 7 CRADD proteins which in turn probably recruit 7 CASP2 to form the PIDDosome (PubMed:17289572). The Death domain mediates a direct interaction with the Death domain of RIPK1 (PubMed:9044836).

The CARD domain mediates a direct interaction with CASP2.

Function

Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572, PubMed:9044836). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253).

Involvement in disease

Intellectual developmental disorder, autosomal recessive 34, with variant lissencephaly

MRT34

A disorder characterized by mild to moderate intellectual disability, megalencephaly or enlarged head circumference, and a mild variant of lissencephaly with anterior-predominant pachygyria with shallow and unusually wide sulci and mildly thickened cortex. Some patients may have seizures.

None

The disease is caused by variants affecting the gene represented in this entry.

Tissue specificity

Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.

Cellular localization

• Cytoplasm
• Nucleus

Alternative names

• RAIDD
• RAIDD
• CRADD
• Death domain-containing protein CRADD
• Caspase and RIP adapter with death domain
• RIP-associated protein with a death domain

Database links

• entrezGene:8738
• omim:603454
• swissprot:P78560

Target type

Proteins

Primary research area

Oncology

Molecular weight

22745Da