CREB3L4
Function
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
Post-translational modifications
N-glycosylated in the C-terminal region.
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
Sequence Similarities
Belongs to the bZIP family. ATF subfamily.
Tissue Specificity
According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass type II membrane protein
- Golgi apparatus membrane
- Single-pass type II membrane protein
- May also be located in Golgi apparatus.
- Processed cyclic AMP-responsive element-binding protein 3-like protein 4
- Nucleus
- Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Alternative names
AIBZIP, CREB4, JAL, CREB3L4, Cyclic AMP-responsive element-binding protein 3-like protein 4, cAMP-responsive element-binding protein 3-like protein 4, Androgen-induced basic leucine zipper protein, Attaching to CRE-like 1, Cyclic AMP-responsive element-binding protein 4, Transcript induced in spermiogenesis protein 40, hJAL, AIbZIP, ATCE1, CREB-4, cAMP-responsive element-binding protein 4, Tisp40